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Synthesis Of N, N′‐Bis(8‐Quinolyl)‐Oligo‐Methylene‐Diamines from 8‐Aminoquinolines
Author(s) -
Horng Y. S.,
Hwang C. C.,
Liao C. C.,
Liu C. S.,
Sheu C. F.,
Yu Y. H.
Publication year - 1980
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.198000011
Subject(s) - chemistry , yield (engineering) , aminoquinolines , alkylation , methylene , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis , materials science , metallurgy
Various N′,N‐bis(8‐quinolyl) trimethylenediamines 3a‐3e have been prepared from the corresponding 8‐aminoquinolines 1a‐1e by direct N ‐alkylation with 1, 3‐dibromopropane in fair yield (25‐51%). N. N′‐bis(8‐quinolyl) ethylenediamines, 3f and 3g , and N,N′‐bis (8‐(6‐methoxyquinolyl) ]tetramethylenediamine. 3h , may only be synthesized in poor yield via the corresponding oxalamides and succinamide.

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