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The Resolution of RS‐Mandelic Acid
Author(s) -
Wong ChiHuey
Publication year - 1979
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.197900015
Subject(s) - mandelic acid , chemistry , yield (engineering) , hydrolysis , ethanol , phenylalanine , organic chemistry , chromatography , amino acid , biochemistry , materials science , metallurgy
Racemic mandelic acid was resolved through R(‐)‐mandelic acid salt with L‐phenylalanine methyl ester in ethanol; the antipode S(+)‐mandelic acid was then recovered from the mother liquid. Both were prepared in high yield and in highly optical purity. Carboxypeptidase A was also used in the separation of S(+)‐mandelic acid via selective hydrolysis of hippuryl‐RS‐mandelic acid. Comparison of the two methods was discussed.