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Photolysis of Isoniazid
Author(s) -
Chiang HungCheh,
Lin LongJin
Publication year - 1978
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.197800022
Subject(s) - chemistry , isonicotinic acid , isoniazid , hydrazone , hydrazide , methanol , acetaldehyde , ethanol , photodissociation , isonicotinamide , medicinal chemistry , photochemistry , organic chemistry , molecule , tuberculosis , hydrogen bond , pathology , medicine
The UV light irradiation of isoniazid (I) in methanol four products, isonicotinic acid (II), isonicotinamide (III), N, N′‐bis(isonicotinic acid)hydrazide (IV) and isonicotinaldehyde isonicotinyl hydrazone (V), in ethanol three products, (III), (IV) and acetaldehyde isonicotinyl hydrazone (VI) were isolated and identified. Also, the photoreaction mechanism of isoniazid in methanol and ethanol were discussed.