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Synthesis of N ‐Substituted Maleimides as Potential Antineoplastic Sulfhydryl Agents
Author(s) -
Liu KangChien,
Jan HonJi
Publication year - 1975
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.197500029
Subject(s) - chemistry , maleimide , dehydration , combinatorial chemistry , organic chemistry , biochemistry
For a purpose of antineoplastic screening, a series of sulfhydryl‐binding agents, N ‐substituted maleimides was prepared. These compounds were obtained by dehydration of the corresponding maleamic acids under suitable conditions in which the formation of maleisoimide by‐products was prevented, IR and UV spectra, as well as the elemental analyses confirmed the structural assignment of our products, A brief discussion on the preparation of N ‐(2,4‐dinitrophenylamino)maleimide was also given.