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Synthesis of N,N 2 ‐Disubstituted DL ‐β‐Asparagines as Potential Hypocholesteremics
Author(s) -
Liu KangChien,
Chen TongBao,
Shih ChingYun
Publication year - 1974
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.197400015
Subject(s) - chemistry , amine gas treating , pyridine , alkyl , medicinal chemistry , double bond , carbon fibers , organic chemistry , stereochemistry , materials science , composite number , composite material
By the addition of equivalent amount of appropriate amine on the carbon‐carbon double bond of N ‐substituted maleamic acids under the influence of pyridine, a number of potential hypocholesteremics, N , N 2 ‐disubstituted DL ‐β‐asparagines was prepared. For all N ‐alkyl‐ and N ‐arylmaleamic acids, the addition proceeded smoothly and resulted in satisfactory yields, but in the cases of N ‐heterocyclic analogs, transamidation was observed to occur simultaneously with the addition reactions.