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Synthesis of 4′‐Phenylflavones
Author(s) -
Hsu K. K.,
Shi J. Y.
Publication year - 1973
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.197300006
Subject(s) - chemistry , methanol , potassium hydroxide , ethanol , flavones , hydrogen peroxide , phosphoric acid , alcohol , selenium , nuclear chemistry , condensation , organic chemistry , chromatography , physics , thermodynamics
In order to study the relationship between structure and activity of flavones, several new 4′‐phenylflavones, 4′‐phenylflavonols, and 4′‐phenylflavanones are synthesized by cyclization of corresponding 4‐phenyl‐2′‐hydroxychalcones with selenium dioxide in hot amyl alcohol, with hydrogen peroxide in cold alkalic ethanol, or with phosphoric acid in hot ethanol, respectively. The 4‐phenyl‐2′‐hydroxychalcones are synthesized by condensation of p ‐phenylbenzaldehyde with various 2′‐hydroxyacetophenones in hot methanol under presence of potassium hydroxide.