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The Reaction of 2‐Methylindole with Pyruvic Acid
Author(s) -
Zee ShengHsu,
Lin ShengYunn,
Fin TeiMin
Publication year - 1973
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.197300004
Subject(s) - chemistry , adduct , pyruvic acid , condensation , condensation reaction , reaction mechanism , medicinal chemistry , organic chemistry , catalysis , physics , thermodynamics
The reaction of 2‐methylindole with pyruvic acid was studied. Two products are found to be depending on experimental conditions, including the 2:2 condensation adduct and the 2:1 condensation adduct. The reaction mechanism evidently involves a 1:1 adduct of 2‐hydroxy‐2‐(2‐methylindol‐3‐yl)‐propionic acid as an intermediate.