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Syntheses of 9‐β‐D‐Ribofuranosylpurine Derivatives as Effective Antiradiation Agents
Author(s) -
Lee KongKo
Publication year - 1971
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.197100015
Subject(s) - chemistry , thiol , in vivo , disulfide bond , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , microbiology and biotechnology , biology
6‐(2‐Hydroxyethyl‐1, 2‐ 14 C) amino‐9‐β‐D‐ribofuranosylpurine (I) and 6‐(2‐mercaptoethyl‐ 35 S) amino‐9‐β‐D‐ribofuranosylpurine (II) were synthesized for the investigation of their in vivo distribution in mice. All the reaction conditions were made by non‐radioactive runs and it was found that thiol compound II was easily oxidized to form the disulfide IV in the purification procedure.