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Studies of Benzofurans as Potential Antimicrobial Agents. II. Synthesis of β‐(2‐Benzofuryl)‐Acrylic Acid and its Derivatives
Author(s) -
Pan Foo,
Wang T.C.
Publication year - 1961
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.196100038
Subject(s) - chemistry , antimicrobial , antifungal , acrylic acid , knoevenagel condensation , yield (engineering) , organic chemistry , nuclear chemistry , microbiology and biotechnology , catalysis , polymer , monomer , materials science , metallurgy , biology
For antimicrobial study, β‐(2‐benzofuryl)acrylic acid has been synthesized in eighty per cent yield by the Knoevenagel reaction. Also prepared were its fifteen derivatives. In a preliminary antifungal test, the free acid exhibited a marked activity, while its functional derivatives were either less active or completely inactive under similar experimental conditions. The detailed results of the antifungal and antibacterial studies will be reported later.