Studies of Benzofurans as Potential Antimicrobial Agents. II. Synthesis of β‐(2‐Benzofuryl)‐Acrylic Acid and its Derivatives | Zendy

Pan Foo | Zendy; Wang T.C. | Zendy

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Studies of Benzofurans as Potential Antimicrobial Agents. II. Synthesis of β‐(2‐Benzofuryl)‐Acrylic Acid and its Derivatives

Author(s) -

Pan Foo,

Wang T.C.

Publication year - 1961

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.196100038

Subject(s) - chemistry , antimicrobial , antifungal , acrylic acid , knoevenagel condensation , yield (engineering) , organic chemistry , nuclear chemistry , microbiology and biotechnology , catalysis , polymer , monomer , materials science , metallurgy , biology

For antimicrobial study, β‐(2‐benzofuryl)acrylic acid has been synthesized in eighty per cent yield by the Knoevenagel reaction. Also prepared were its fifteen derivatives. In a preliminary antifungal test, the free acid exhibited a marked activity, while its functional derivatives were either less active or completely inactive under similar experimental conditions. The detailed results of the antifungal and antibacterial studies will be reported later.

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