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Synthesis of N‐p‐Chlorophenyl‐N′, N′‐Dimethylurea
Author(s) -
Chiang FanTih
Publication year - 1955
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.195500019
Subject(s) - chemistry , dimethylamine , chlorobenzene , chloride , ethylene , isocyanate , yield (engineering) , medicinal chemistry , nuclear chemistry , organic chemistry , catalysis , materials science , metallurgy , polyurethane
N‐p‐Chlorophenyl‐N′, N′‐dimethylurea (CMU) was synthesized by the reaction of p‐chlorophenyl isocyanate with dimethylamine in mono‐chlorobenzene. The yield was 82.17%. p‐Chlorophenyl isocyanate was prepared by heating p‐chlorocarbamyl chloride, which was synthesized by phosgenation of p‐chloroaniline in ethylene chloride. p‐Chlorophenyl carbamyl chloride was crystallized as colorless needles from ethylene chloride.