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Atomic charges derived from semiempirical methods
Author(s) -
Besler Brent H.,
Merz Kenneth M.,
Kollman Peter A.
Publication year - 1990
Publication title -
journal of computational chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 188
eISSN - 1096-987X
pISSN - 0192-8651
DOI - 10.1002/jcc.540110404
Subject(s) - mndo , atomic charge , charge (physics) , ab initio , basis set , scaling , chemistry , force field (fiction) , computational chemistry , point particle , point (geometry) , atomic physics , physics , classical mechanics , quantum mechanics , density functional theory , molecule , mathematics , geometry
It is demonstrated that semiempirical methods give electrostatic potential (ESP) derived atomic point charges that are in reasonable agreement with ab initio ESP charges. Furthermore, we find that MNDO ESP charges are superior to AM1 ESP charges in correlating with ESP charges derived from the 6‐31G* basis set. Thus, it is possible to obtain 6‐31G* quality point charges by simply scaling MNDO ESP charges. The charges are scaled in a linear ( y = Mx ) manner to conserve charge. In this way researchers desiring to carry out force field simulations or minimizations can obtain charges by using MNDO, which requires much less computer time than the corresponding 6‐31G* calculation.