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Interaction energy studies of pyrrolopyrimidine nucleoside antibiotics: Sangivamycin
Author(s) -
Sanyal Nitish K.,
Ojha Rajendra Prasad,
Roychoudhury M.,
Tiwari S. N.
Publication year - 1986
Publication title -
journal of computational chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 188
eISSN - 1096-987X
pISSN - 0192-8651
DOI - 10.1002/jcc.540070105
Subject(s) - chemistry , nucleoside , nucleic acid , stereochemistry , biochemistry
Interaction energy calculations have been employed to study the biological activity of sangivamycin. The interaction energy values and the site of association of the analog have been compared with those for the nucleic acid bases. A comparative estimation of the results with those of other pyrrolopyrimidine nucleosides (Tubercidin and Toyocamycin) has been made. These studies suggest that the activity of pyrrolopyrimidine analogs is of the following orderToyocamycin > Tubercidin > Sangivamycinwhich is in general agreement with the experimental results.