Cover Image, Volume 38, Issue 7

The tumor suppressor protein p53 is a small transcription factor (393 amino acid) that binds to specific DNA sequences and regulates the expression of genes involved in DNA repair, cell cycle arrest, and apoptotic cell death. Mutations in this protein have been shown to result in a partial or total loss of its ability to bind DNA and correlated with increased probabilities of developing tumors. On page 467, Valdebenito‐Maturana et al., employ computational chemistry tools to characterize the structural effects that point mutations have on p53 function and cancer development. DOI: 10.1002/jcc.24712