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Inside Cover, Volume 34, Issue 28
Publication year - 2013
Publication title -
journal of computational chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.907
H-Index - 188
eISSN - 1096-987X
pISSN - 0192-8651
DOI - 10.1002/jcc.23442
Subject(s) - cover (algebra) , rhodopsin , physics , chemistry , humanities , computer science , crystallography , retinal , art , mechanical engineering , biochemistry , engineering
The cover shows the retinal π‐conjugated system in the wild‐type (top) and hS186W mutant (bottom) of human rhodopsin. On page 2460 , Erix Wiliam Hernández‐ Rodríguez, Ana Lilian Montero‐Alejo, Rafael López, Elsa Sánchez‐García, Luis Alberto Montero‐Cabrera, and José Manuel García de la Vega use the method of deformed atoms in molecules (DAM) to study the electron distribution in 11‐cis‐retinal in wild‐type rhodopsin and two mutations associated with retinitis pigmentosa disease: hM207R and hS186W. The apparition of an electron density gap in mutants is related to a loss of charge delocalization. The planarity of Schiff‐base regions of the retinal chain in rhodopsin is affected by changes in the electron density.