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Cover Image, Volume 34, Issue 10
Publication year - 2013
Publication title -
journal of computational chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.907
H-Index - 188
eISSN - 1096-987X
pISSN - 0192-8651
DOI - 10.1002/jcc.23274
Subject(s) - cover (algebra) , computer science , protein data bank (rcsb pdb) , epitope , image (mathematics) , information retrieval , citation , computer graphics (images) , computational biology , artificial intelligence , library science , biology , biochemistry , genetics , antibody , mechanical engineering , engineering
Erythropoeitin (Epo) is a treatment for anemia that elicits an immune response in some patients. The figure (from pdb id 1eer, rendered by PyMol) shows Epo (ribbon) and its receptor (surface), highlighting by color and ribbon thickness the locations of predicted T‐cell epitopes within Epo. The computational method by Yoonjoo Choi, Karl E. Griswold, and Chris Bailey‐Kellogg on page 879 redesigns such therapeutic proteins so as to have minimal predicted T‐cell epitope content but still maintain native‐like structural and sequence properties.