Premium
Exploring the potential energy surface of retinal, a comparison of the performance of different methods
Author(s) -
Blomgren Fredrik,
Larsson Sven
Publication year - 2005
Publication title -
journal of computational chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.907
H-Index - 188
eISSN - 1096-987X
pISSN - 0192-8651
DOI - 10.1002/jcc.20210
Subject(s) - planarity testing , retinal , ground state , chemistry , bond length , potential energy surface , molecule , molecular geometry , computational chemistry , density functional theory , molecular physics , atomic physics , crystallography , physics , biochemistry , organic chemistry
The ground state structure of retinal has been investigated. We found that DFT and CASSCF produce different results for the bond length alternation in a model system of retinal. Quantum mechanics/molecular mechanics calculations including the closest surrounding amino acids have been performed, using DFT and CASSCF to calculate the structure of retinal in the protein cavity. The planarity of the retinal molecule is affected by the surrounding protein. DFT and CASSCF produce different twist angles. The difference between CASSCF and DFT appears to be related to the positively charged nitrogen of the Schiff base, which leads to different π‐bond orders produced by the two methods. © 2005 Wiley Periodicals, Inc. J Comput Chem 26: 738–742, 2005