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Neuroprotective activities of bacopa, lycopene, astaxanthin, and vitamin B12 combination on oxidative stress‐dependent neuronal death
Author(s) -
Castelli Vanessa,
Melani Francesco,
Ferri Claudio,
d'Angelo Michele,
Catanesi Mariano,
Grassi Davide,
Benedetti Elisabetta,
Giordano Antonio,
Cimini Annamaria,
Desideri Giovambattista
Publication year - 2020
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.29722
Subject(s) - neuroprotection , oxidative stress , nutraceutical , programmed cell death , astaxanthin , pharmacology , medicine , chemistry , biology , biochemistry , apoptosis , carotenoid
Oxidative stress is considered the common effector of the cascade of degenerative events in many neurological conditions. Thus, in this paper we tested different nutraceuticals in H 2 O 2 in vitro model to understand if could represent an adjuvant treatment for neurological diseases. In this study, nutraceuticals bacopa, lycopene, astaxanthin, and vitamin B12 were used alone or in combination in human neuronal differentiated SH‐SY5Y cells upon hydrogen peroxide‐induced injury and neuroprotective, neuronal death pathways were analyzed. The nutraceuticals analyzed were able to protect H 2 O 2 cytotoxic effects, through increasing cell viability and proteins involved in neuroprotection pathways and restoring proteins involved in cell death pathways. On this basis, it is possible to propose the use of these compounds as dietary supplement for the prevention or as adjuvant to the only symptomatic treatments so far available for neurodegenerative diseases.