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Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis
Author(s) -
Saccol Renata da Silva Pereira,
Silveira Karine Lanes,
Manzoni Alessandra Guedes,
Abdalla Fátima Husein,
Oliveira Juliana Sorraila,
Dornelles Guilherme Lopes,
Barbisan Fernanda,
Passos Daniela Ferreira,
Casali Emerson André,
Andrade Cinthia Melazzo,
Cruz Ivana Beatrice Mânica,
Leal Daniela Bitencourt Rosa
Publication year - 2020
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.29502
Subject(s) - quercetin , pharmacology , arthritis , antioxidant , oxidative stress , chemistry , genotoxicity , thiobarbituric acid , cytotoxicity , glutathione , reactive oxygen species , catalase , rheumatoid arthritis , biochemistry , medicine , immunology , lipid peroxidation , toxicity , enzyme , in vitro , organic chemistry
Rheumatoid arthritis is a highly debilitating inflammatory autoimmune disease which is characterized by joint destruction. The present study sought to investigate the effect of quercetin in rats with complete Freund's adjuvant‐induced arthritis. Animals were divided into control/saline, control/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg) arthritis/saline, and arthritis/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg); the treatments were administered for 45 days. Biochemical, oxidative stress, genotoxicity, and cytotoxicity parameters were evaluated. All doses of quercetin reduced the levels of aspartate aminotransferase, thiobarbituric acid‐reactive substances, and reactive oxygen species; however, only treatment with 25 or 50 mg/kg increased catalase activity. Total thiol and reduced glutathione levels were not significantly affected by the induction nor by the treatments. Genotoxicity assessed by DNA damage, and cytotoxicity through picogreen assay, decreased after treatments with quercetin. Our results present evidence of the antioxidant, cytoprotective, genoprotective and hepatoprotective, and effects of quercetin, demonstrating its potential as a candidate for coadjuvant therapy.