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Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC)
Author(s) -
Liu Shiyi,
Li Saijiao,
Wang Yanqing,
Wang Feiyan,
Zhang Li,
Xian Shu,
Yang Dongyong,
Yuan Mengqin,
Dai Fangfang,
Zhao Xin,
Liu Yuping,
Jin Yumeng,
Zeng Zihang,
Mahgoub Omer Kamal Ahmed,
Zhou Chenliang,
Cheng Yanxiang
Publication year - 2020
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.29479
Subject(s) - immune system , clear cell renal cell carcinoma , stromal cell , cancer research , biology , immunology , medicine , renal cell carcinoma , pathology
In this study, we attempted to evaluate the prognostic value of infiltrating immune/stromal cells in clear cell renal cell carcinoma (ccRCC), by using the immune scores and stromal scores based on the “Estimation of STromal and Immune cells in MAlignant Tumours using Expression data” algorithm to represent the levels of infiltrating immune cells and stromal cells. We found that the infiltrating immune cells were associated with poor prognosis of ccRCC. To assess the role of infiltrating immune cells in ccRCC cells, first, we performed differentially expressed genes analysis and functional analysis for validation. The results showed that the underlying mechanism by which infiltrating immune cells promoted cancer progression involved in regulating the nuclear division, angiogenesis, and immune response. Next, we investigated the relationship between infiltrating immune cells and mutations in ccRCC cells. We found that the infiltrating immune cells have certain effects on genetic mutations. In conclusion, infiltrating immune cells within the tumor microenvironment can be used to predict prognosis in ccRCC.