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Vitamin D receptor gene polymorphism is associated with multiple myeloma
Author(s) -
Rui Hongbing,
Liu Ying,
Lin Meiying,
Zheng Xiaoqiang
Publication year - 2020
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.29135
Subject(s) - calcitriol receptor , taqi , foki , allele , genotype , haplotype , biology , linkage disequilibrium , genetics , microbiology and biotechnology , polymerase chain reaction , gene , polymorphism (computer science)
Objectives The aim of this study was to explore the Vitamin D receptor ( VDR ) gene polymorphism and its association with multiple myeloma (MM) development. Methods The peripheral blood of 40 MM cases and 84 healthy controls were collected. Polymerase chain reaction (PCR) and DNA sequencing were applied to detect VDR gene polymorphism (including: FokI, BsmI, ApaI, and TaqI). SHESIS biological information software was used to analyze genotypes, alleles, linkage disequilibrium (LD), haplotype distribution, and their association with MM. Results Compared with controls, the MM group had a significantly higher frequency of the A allele in BsmI site (8.7% vs 2.4%) and C allele in the TaqI site (10.5% vs 3.6%). These two alleles were closely associated with an increased risk of MM ( P = .025; P = .030). The highly rare genotypes (BsmI‐AA and TaqI‐CC) were found in one patient with MM. Conclusion VDR gene polymorphisms may be a molecular marker of MM risk.