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Application of nanomaterials in three‐dimensional stem cell culture
Author(s) -
GholizadehGhaleh Aziz Shiva,
Pashaiasl Maryam,
Khodadadi Khodadad,
Ocheje Onuche
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.29133
Subject(s) - multidisciplinary approach , stem cell , nanotoxicology , nanotechnology , petri dish , engineering ethics , biology , engineering , microbiology and biotechnology , materials science , sociology , nanoparticle , social science , genetics
Petri dish cultured cells have for long provided scientists an aperture to understanding cell's behavior both in normal and disease states as well as in vitro and in vivo. But recent advances have brought to light how the architecture and composite nature of the immediate environment within which the cell is proliferated can profoundly influence its phenotypic features and functions, thus making obvious, limitations of the conventional two‐dimensional cell culture despite it cost effectiveness. Fortunately, the transition to three‐dimensional (3D) cell culture has occurred concurrently with expanded knowledge of nanoscience and materials, thereby lending significant impetus for innovative research. This review is focused on the application of nanoparticles in 3D stem cell breeding, recent trends and developments in medical sciences for improved drug delivery, and treatment approaches to some human diseases. We also reviewed prevailing challenges and concerns of nanotoxicity as it continues to impede and delay clinical applications as well the ongoing concerted and multidisciplinary efforts to overcome them.