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LncRNA Erbb4‐IR promotes esophageal squamous cell carcinoma (ESCC) by downregulating miR‐145
Author(s) -
Zhang Yan,
Zhang Li,
Wang Ruimin,
Wang Bin,
Hua Peiyan,
Li Jindong
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.29023
Subject(s) - erbb4 , cancer research , downregulation and upregulation , apoptosis , cell growth , microrna , cell , chemistry , medicine , signal transduction , gene , biochemistry , receptor tyrosine kinase
Erbb4‐IR is a recently identified lncRNA with pivotal functions in renal injury. The present study investigated the roles of Erbb4‐IR in esophageal squamous cell carcinoma (ESCC). It was observed that Erbb4‐IR was upregulated in tumor tissues of patients with ESCC. Plasma levels of Erbb4‐IR in patients with ESCC were positively correlated with expression levels of Erbb4‐IR in tumor tissues. MicroRNA‐145 (miR‐145) was downregulated in tumor tissues and inversely correlated with Erbb4‐IR only in tumor tissues. Erbb4‐IR overexpression led to downregulated miR‐145, and increased rates of ECSS cell proliferation and decreased rates of ECSS cell apoptosis. Overexpression of miR‐145 showed no significant effects on Erbb4‐IR expression, but played an opposite role on cancer cell proliferation and apoptosis. In addition, miR‐145 overexpression attenuated the effects of Erbb4‐IR overexpression. Therefore, lncRNA Erbb4‐IR may promote ESCC by downregulating miR‐145.