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Circular RNA expression profile of knee condyle in osteoarthritis by illumina HiSeq platform
Author(s) -
Xiao Ke,
Xia Zenan,
Feng Bin,
Bian Yanyan,
Fan Yu,
Li Zeng,
Wu Zhihong,
Qiu Guixing,
Weng Xisheng
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.29014
Subject(s) - circular rna , microrna , osteoarthritis , rna , gene , computational biology , gene expression , bioinformatics , biology , medicine , genetics , pathology , alternative medicine
Abstract Osteoarthritis (OA) is the utmost commonly arising joint disease. Knee condyles play an essential role during OA progression. Circular RNA (or circRNA) is a novel kind of RNA, which, unlike the well‐known linear RNA, plays an important regulatory role in OA on the basis of a previous research. In our study, expression of circRNAs in OA knee condyle was measured by illumine sequencing platform. A total of 197 differentially expressed circRNAs, such as hg38_circ_0007474 and hg38_circ_0000118 were identified, and 21 target miRNAs, 2466 source genes and 166 394 circRNA‐miRNA‐mRNA pairs were predicted. Further analysis was applied on three OA‐related circRNAs (hsa_circ_0045714, hsa_circ_0002485, and hsa_circ_0005567). The results were partly verified by previous studies. Further biological research is needed to unfold the possible pathway and therapeutic target of OA.