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Endothelins and their receptors in embryo implantation
Author(s) -
Mihanfar Aynaz,
Sadigh Aydin Raei,
Fattahi Amir,
Latifi Zeinab,
HasanzadehMoghadam Mahsa,
Samadi Mahrokh,
Farzadi Laya,
Hamdi Kobra,
Ghasemzadeh Aliyeh,
Nejabati Hamid Reza,
Nouri Mohammad
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28983
Subject(s) - endothelins , embryo , receptor , infertility , biology , endometrium , uterus , microbiology and biotechnology , bioinformatics , endocrinology , endothelin receptor , medicine , pregnancy , genetics
As a critical stage of pregnancy, the implantation of blastocysts into the endometrium is a progressive, excessively regulated local tissue remodeling step involving a complex sequence of genetic and cellular interplay executed within an optimal time frame. For better understanding the causes of infertility and, more importantly, for developing powerful strategies for successful implantations and combating infertility, an increasing number of recent studies have been focused on the identification and study of newly described substances in the reproductive tree. The endothelins (ET), a 21‐aminoacidic family of genes, have been reported to be responsible for the contraction of vascular and nonvascular smooth muscles, including the smooth muscles of the uterus. Therefore, this review aims to comprehensively discuss the physiological role of endothelins and signaling through their receptors, as well as their probable involvement in the implantation process.