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lncRNA DILC is downregulated in osteoarthritis and regulates IL‐6 expression in chondrocytes
Author(s) -
Huang Junfeng,
Liu Lijun,
Yang Jinxing,
Ding Jinglun,
Xu Xu
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28880
Subject(s) - osteoarthritis , downregulation and upregulation , long non coding rna , cancer research , pathogenesis , medicine , gene , immunology , biology , pathology , genetics , alternative medicine
Excessive production of interleukin 6 (IL‐6) is involved in the pathogenesis of osteoarthritis. It has been reported that long noncoding RNA (lncRNA) DILC inhibited IL‐6 to regulate liver cancer stem cells. Therefore, lncRNA DILC may also participate in osteoarthritis. We found that lncRNA DILC was downregulated, while IL‐6 was upregulated in plasma of osteoarthritis patients comparing to the control group. Levels of plasma lncRNA DILC and IL‐6 were significantly and inversely correlated only in patients with osteoarthritis. Downregulation of lncRNA DILC effectively distinguished patients with osteoarthritis from the control group. Overexpression of lncRNA DILC resulted in inhibited IL‐6 expression in chondrocytes, while treatment with exogenous IL‐6 did not affect lncRNA DILC expression. However, lncRNA DILC overexpression did not affect the proliferation and apoptosis of chondrocytes. Therefore, lncRNA DILC is downregulated in osteoarthritis and regulates IL‐6 expression in chondrocytes.