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Role of heterogeneous nuclear ribonucleoprotein K in tumor development
Author(s) -
Chen Yuting,
Zeng Ying,
Xiao Zheng,
Chen Shi,
Li Yukun,
Zou Juan,
Zeng Xi
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28867
Subject(s) - heterogeneous nuclear ribonucleoprotein , ribonucleoprotein , heterogeneous ribonucleoprotein particle , rna splicing , carcinogenesis , rna binding protein , biology , translation (biology) , microbiology and biotechnology , rna , nuclear export signal , alternative splicing , suppressor , transcription (linguistics) , cancer research , cell nucleus , cytoplasm , messenger rna , gene , genetics , linguistics , philosophy
Abstract Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is an RNA/DNA special binding protein that participates in regulating the expression of related genes, transcription, RNA alternative splicing, translation, posttranslational modification, cell signal transduction, cell movement, interacts with ncRNAs, and induces angiogenesis. Moreover, several cellular functions forcefully indicated that hnRNP K participates in tumorigenesis. Numerous studies indicated hnRNP K is aberrantly elevated in multiple tumors. In addition, hnRNP K abnormal accumulation in cytoplasmic is also associated with poor prognosis. This suggests that hnRNP K may play a role in the development and progression of tumors. However, related studies demonstrated that hnRNP K acts as a tumor suppressor to suppress tumor formation. Therefore, this paper aims to explore the role of hnRNPK in tumors.