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Plasma metabolite biomarkers related to secondary hyperparathyroidism and parathyroid hormone
Author(s) -
Shen Qixia,
Xiang Wenyu,
Ye Sen,
Lei Xin,
Wang Lefeng,
Jia Sha,
Shao Xue,
Weng Chunhua,
Shen Xiujin,
Wang Yucheng,
Feng Shi,
Qu Lihui,
Wang Cuili,
Chen Jianghua,
Zhang Ping,
Jiang Hong
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28846
Subject(s) - secondary hyperparathyroidism , parathyroid hormone , medicine , endocrinology , hyperphosphatemia , hyperparathyroidism , metabolite , parathyroidectomy , transplantation , chemistry , calcium
Background Hyperphosphatemia, hypocalcemia, and elevation of parathyroid hormone (PTH) are typical abnormalities of uremic patients with Secondary hyperparathyroidism (SHPT). However, metabolic imbalance associated with SHPT is not well understood. Methods A total of 15 SHPT patients with an intact parathyroid hormone (iPTH) level > 600 pg/mL were set as preoperative (PR) group, 15 age‐ and gender‐matched controls who had undergone parathyroidectomy plus forearm transplantation because of hyperparathyroidism and achieved an iPTH level <150 pg/mL were set as postoperative (PO) group. Metabolite profiling of these 30 uremic patients and five healthy controls (HC) was performed using ultra performance liquid chromatography‐mass spectrometry. Results Five differential metabolites, including allyl isothiocyanate, L ‐phenylalanine, D ‐Aspartic acid, indoleacetaldehyde, and D ‐galactose correlated with PTH were identified in this study. Taking them as a biomarker signature, PR group can be distinguished from HC group with an area under the curve (AUC) of 0.947 (95% CI, 0.76‐1) and PO group with an AUC of 0.6 (95% CI, 0.38‐0.807). Conclusions The serum metabolome correlated with PTH is successfully demonstrated for a better understanding of the pathogenesis of SHPT.