Premium
Role of two‐component regulatory systems in intracellular survival of Mycobacterium tuberculosis
Author(s) -
Li Xue,
Lv Xi,
Lin Yanping,
Zhen Junfeng,
Ruan Cao,
Duan Wei,
Li Yue,
Xie Jianping
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28792
Subject(s) - two component regulatory system , response regulator , histidine kinase , mycobacterium tuberculosis , signal transduction , biology , intracellular , regulator , kinase , microbiology and biotechnology , bacteria , gene , tuberculosis , regulation of gene expression , genetics , bacterial protein , mutant , medicine , pathology
The typical two‐component regulatory systems (TCSs), consisting of response regulator and histidine kinase, play a central role in survival of pathogenic bacteria under stress conditions such as nutrient starvation, hypoxia, and nitrosative stress. A total of 11 complete paired two‐component regulatory systems have been found in Mycobacterium tuberculosis , including a few isolated kinase and regulatory genes. Increasing evidence has shown that TCSs are closely associated with multiple physiological process like intracellular persistence, pathogenicity, and metabolism. This review gives the two‐component signal transduction systems in M. tuberculosis and their signal transduction roles in adaption to the environment.