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Cancer drug resistance: A fleet to conquer
Author(s) -
Hussain Showket,
Singh Ankita,
Nazir Sheeraz Un,
Tulsyan Sonam,
Khan Asiya,
Kumar Ramesh,
Bashir Nasreena,
Tanwar Pranay,
Mehrotra Ravi
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28782
Subject(s) - disease , drug resistance , cancer , microvesicles , cancer drugs , efflux , drug , biology , bioinformatics , resistance (ecology) , medicine , drug discovery , microrna , gene , computational biology , pharmacology , genetics , ecology
Cancer is a disease that claims millions of lives each year across the world. Despite advancement in technologies and therapeutics for treating the disease, these modes are often found to turn ineffective during the course of treatment. The resistance against drugs in cancer patients stems from multiple factors, which constitute genetic heterogeneity like gene mutations, tumor microenvironment, exosomes, miRNAs, high rate of drug efflux from cells, and so on. This review attempts to collate all such known and reported factors that influence cancer drug resistance and may help researchers with information that might be useful in developing better therapeutics in near future to enable better management of several cancers across the world.