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Expression of long noncoding RNAs in breast cancer in relation to reproductive factors and tumor characteristics
Author(s) -
GhafouriFard Soudeh,
Taheri Mohammad,
Omrani Mir Davood,
Kholghi Oskooei Vahid
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28671
Subject(s) - breast cancer , biology , long non coding rna , downregulation and upregulation , gene , cancer research , gene expression , gene expression profiling , cancer , genetics
Long noncoding RNAs (lncRNA) regulate expressions of several cancer‐related genes and pathways. Expression profiling of lncRNAs would pave the way for identification of dysregulated pathways in cancer. We assessed expression of FAS‐anti sense 1 (FAS‐AS1) , Taurine Upregulated 1 (TUG1) , OPA‐interacting protein 5‐AS1 (OIP5 ‐ AS1) , nuclear‐enriched abundant transcript 1 (NEAT1) , and highly upregulated in liver cancer ( HULC) in breast tumor tissues and adjacent noncancerous tissues (ANCTs). TUG1 was downregulated in tumoral tissues. We found associations between TUG1 expression and mitotic rate, NEAT1 expression and breast feeding duration as well as FAS‐AS1 and OPI5 expressions and menarche age. A combination of transcript levels of all genes had 88.5% sensitivity and 42.3% specificity in breast cancer diagnosis. The current study provides evidence for the contribution of lncRNAs in breast cancer in relation to reproductive factors and tumor characteristics.