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Effects of quercetin on microRNAs: A mechanistic review
Author(s) -
Akbari Kordkheyli Vahid,
Khonakdar Tarsi Abbas,
Mishan Mohammad A.,
Tafazoli Alireza,
Bardania Hassan,
Zarpou Setareh,
Bagheri Abouzar
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28663
Subject(s) - microrna , quercetin , computational biology , biology , genetics , biochemistry , gene , antioxidant
MicroRNA (miRNA)‐dependent pathways are one of the newest gene regulation mechanisms in various diseases, particularly in cancers. miRNAs are endogenous noncoding RNAs with about 18 to 25 nucleotide length, which can regulate the expression of at least 60% of human total genome posttranscriptionally. Quercetin is the most abundant flavonoid in a variety of fruits, flowers, and medical herbs, known as a strong free radical scavenger that could show antioxidant, anti‐inflammatory, and antitumor activities. Recent studies also reported its strong impact on various miRNA expressions in different abnormalities. In this review, we aimed to summarize the studies focused on the effects of quercetin on different miRNA expressions to more clear the main possible mechanisms of quercetin influences and introduce it as a beneficial agent for regulation of miRNAs in various biological directions.