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Natural compounds with DPP‐4 inhibitory effects: Implications for the treatment of diabetes
Author(s) -
Yaribeygi Habib,
Atkin Stephen L.,
Sahebkar Amirhossein
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28467
Subject(s) - sitagliptin , hypoglycemia , diabetes mellitus , dipeptidyl peptidase 4 , medicine , pharmacology , type 2 diabetes , endogeny , chemistry , endocrinology
Dipeptidyl peptidase‐4 (DPP‐4) inhibitors are antidiabetes agents that decrease blood glucose by preventing the degradation of endogenous glucagon‐like peptide‐1. The first DPP‐4 was sitagliptin followed by several other agents in the class introduced to manage diabetes. Recent studies have suggested that naturally occurring compounds can exert an antidiabetes effect through DPP‐4 inhibition. Such compounds may have a place in the treatment of diabetes within the diet; however, while DPP‐4 inhibition alone is not associated with hypoglycemia, in combinations with other medication hypoglycemia can result, therefore, it is critical to know what herbal or food‐based compounds may have these activities in the management of diabetes patients. In this review, we have outlined the compounds that have DPP‐4 inhibition that may have utility in the treatment of diabetes.