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Hepatoprotective effects of phosphatidylserine liposomes on carbon tetrachloride‐induced hepatotoxicity in rats
Author(s) -
YousefiManesh Hasan,
Shirooie Samira,
Partoazar Alireza,
Nikoui Vahid,
Estakhri Mohammad Reza Abdollahzadeh,
Bakhtiarian Azam
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28464
Subject(s) - carbon tetrachloride , chemistry , superoxide dismutase , malondialdehyde , alkaline phosphatase , antioxidant , pharmacology , liposome , catalase , reactive oxygen species , oxidative stress , biochemistry , phosphatidylserine , enzyme , medicine , phospholipid , organic chemistry , membrane
It has been proposed carbon tetrachloride (CCl 4 ) intoxication due to the production of free radicals and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) overload results hepatotoxicity. Phosphatidylserine (PS) has shown antioxidant activity in numerous studies. Therefore, this study was aimed to investigate the effects of PS liposomes treatment against the CCl 4 ‐induced hepatotoxicity in a rat model. Male Wistar rats were treated with PS (10 mg/kg, oral) or phosphatidylcholine liposomes (PC) (10 mg/kg, oral) for 3 days before CCl 4 (2 ml/kg; ip once on the third day) injection. The serum level of ALT, AST, and ALP were measured. Also, antioxidant assays were performed. Administration of PS with CCl 4 significantly inhibited alterations in the serum levels of AST, ALP ( ** P < 0.01), and ALT ( *** P < 0.001) compared with control group. Furthermore, measurement of malondialdehyde (MDA), catalase (CAT), and superoxide dismutase (SOD) levels indicated that PS significantly reduced reactive oxygen species. The results of the present study showed the hepatoprotective effects of PS against CCl 4 ‐induced hepatotoxicity in rats.