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Perineural invasion is related to p38 mitogen‐activated protein kinase pathway activation and promotes tumor growth and chemoresistance in pancreatic cancer
Author(s) -
Gu Jiangning,
Xu Wei,
Peng Chenghong,
Zhu Youwei,
Wang Di,
Wang Xuelong,
Li Ying,
Wei Gang,
Zhang Zhiqiang,
Zhong Yiming,
Zhao Shulin,
Shi Minmin,
Cheng Dongfeng,
Ying Xiayang,
Jin Jiabin,
Chen Hao
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28457
Subject(s) - pancreatic cancer , protein kinase a , cancer research , dorsal root ganglion , perineural invasion , metastasis , signal transduction , medicine , cancer , tumor promotion , kinase , biology , microbiology and biotechnology , carcinogenesis , dorsum , anatomy
Metastasis is a key component of cancer progression and is strongly associated with poor prognosis. Perineural invasion is thought to be related to pain, tumor recurrence, and other conditions. However, the exact molecular mechanism is unclear. This study was conducted to identify the key components and signaling pathways involved in the perineural invasion of pancreatic cancer and alterations in the phenotype after the interaction between the dorsal root ganglion (DRG) and pancreatic cancer cells. The results indicated that the p38 mitogen‐activated protein kinase signaling pathway was activated after coculture of the DRG and pancreatic cancer cells and lead to the promotion of cell growth and chemoresistance.