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microRNA‐510‐5p promotes thyroid cancer cell proliferation, migration, and invasion through suppressing SNHG15
Author(s) -
Liu Yongcun,
Li Junli,
Li Meng,
Li Feng,
Shao Yuan,
Wu Liping
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28454
Subject(s) - thyroid cancer , cancer research , microrna , thyroid , cell growth , cancer , long non coding rna , medicine , metastasis , thyroid function , oncology , downregulation and upregulation , biology , gene , biochemistry , genetics
SNHG15 has been suggested to be correlated with clinical progression and prognosis, and function as tumor suppressive long noncoding RNA in thyroid cancer at our previous study. SNHG15 was proposed to be a potential target for miR‐510‐5p at LncBase Predicted database. Thus, the aim of this study was to explore the relationship between miR‐510‐5p and SNHG15 in thyroid cancer, and the clinical significance of miR‐510‐5p in patients with thyroid cancer. In our results, levels of miR‐510‐5p expression were increased in thyroid cancer tissues and cell lines compared with adjacent normal thyroid tissues and normal thyroid cell line, respectively. There was a statistically negative correlation between SNHG15 expression and miR‐510‐5p expression in thyroid cancer tissues. Moreover, miR‐510‐5p directly bound to SNHG15, and negatively regulated SNHG15 expression in thyroid cancer cells. Furthermore, miR‐510‐5p promoted thyroid cancer cell proliferation, migration, and invasion through suppressing SNHG15. Finally, high miR‐510‐5p expression was observed in tumor tissues with advanced clinical stage or lymph node metastasis. In conclusion, we provide evidence to support a pivotal role for miR‐510‐5p in regulating thyroid cancer cell proliferation, migration, and invasion.