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PPAR‐γ: Its ligand and its regulation by microRNAs
Author(s) -
Seiri Parvaneh,
Abi Abbas,
Soukhtanloo Mohammad
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28419
Subject(s) - peroxisome proliferator activated receptor , nuclear receptor , microrna , biology , receptor , microbiology and biotechnology , function (biology) , lipid metabolism , peroxisome , signal transduction , transcription factor , gene , endocrinology , biochemistry
Peroxisome proliferator‐activated receptors (PPARs) belong to the nuclear receptor superfamily. PPARs are categorized into three subtypes, PPARα, β/δ, and γ, encoded by different genes, expressed in diverse tissues and participate in various biological functions and can be activated by their metabolic derivatives in the body or dietary fatty acids. The PPAR‐γ also takes parts in the regulation of energy balance, lipoprotein metabolism, insulin sensitivity, oxidative stress, and inflammatory signaling. It has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis, and cancers. Among various cellular and molecular targets that are able to regulate PPAR‐γ and its underlying pathways, microRNAs (miRNAs) appeared as important regulators. Given that the deregulation of these molecules via targeting PPAR‐γ could affect initiation and progression of various diseases, identification of miRNAs that affects PPAR‐γ could contribute to the better understanding of roles of PPAR‐γ in various biological and pathological conditions. Here, we have summarized the function and various ligands of PPAR‐γ and have highlighted various miRNAs involved in the regulation of PPAR‐γ.