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Role of the transforming growth factor‐β signaling pathway in the pathogenesis of colorectal cancer
Author(s) -
Soleimani Atena,
Pashirzad Mehran,
Avan Amir,
Ferns Gordon A.,
Khazaei Majid,
Hassanian Seyed Mahdi
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28331
Subject(s) - pathogenesis , transforming growth factor , colorectal cancer , signal transduction , cancer research , mouse model of colorectal and intestinal cancer , growth factor , transforming growth factor beta , cancer , medicine , biology , microbiology and biotechnology , genetics , immunology , receptor
The transforming growth factor‐β (TGF‐β) signaling pathway plays an important role in cancer cell proliferation, growth, metastasis, and apoptosis. It has been shown that TGF‐β acts as a tumor suppressor in the early stages of the disease, and as a tumor promoter in its late stages. Mutations in the TGF‐β signaling components, the TGF‐β receptors and cytoplasmic signaling transducers, are frequently observed in colorectal carcinomas. Exploiting specific TGF‐β receptor agonist and antagonist with antitumor properties may be a way of controlling cancer progression. This review summarizes the regulatory role of TGF‐β signaling in the pathogenesis of colorectal cancer.