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Downregulation of lnRNA‐NEF is involved in the postoperative cancer distant recurrence in prostate carcinoma patients
Author(s) -
Wan Xiaodong,
Xiang Jun,
Zhang Qimin,
Bian Cuidong
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28237
Subject(s) - downregulation and upregulation , transforming growth factor , prostate cancer , cancer research , cell culture , cell , cancer , medicine , stage (stratigraphy) , biology , gene , paleontology , biochemistry , genetics
LnRNA‐NEF has characterized functionality only in liver cancer. In the present study, we observed that plasma lnRNA‐NEF was downregulated, while plasma transforming growth factor‐β1 (TGF‐β1) was upregulated in patients with early‐stage prostate carcinoma (PC) than in healthy controls. The levels of plasma lnRNA‐NEF and plasma TGF‐β1 were inversely correlated in patients with PC but not in healthy controls. After surgical resection, the follow‐up was performed for 5 years. It was observed that lnRNA‐NEF was further decreased in patients with distant recurrence (DR), but not in patients with local recurrence and nonrecurrence. lnRNA‐NEF overexpression caused inhibited TGF‐β1 expression in cells of PC cell lines, while TGF‐β1 overexpression failed to affect lnRNA‐NEF expression. LnRNA‐NEF overexpression inhibited, while the TGF‐β1 overexpression promoted the migration and invasion of cells of PC cell lines. TGF‐β1 overexpression partially rescued the inhibited migration and invasion of cells of PC cell lines caused by the lnRNA‐NEF overexpression. Therefore, the downregulation of lnRNA‐NEF may contribute to the postoperative DR in patients with PC through the interactions with TGF‐β1.