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The effects of microRNAs in activating neovascularization pathways in diabetic retinopathy
Author(s) -
Satari Mahbobeh,
Aghadavod Esmat,
Mirhosseini Naghmeh,
Asemi Zatollah
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28227
Subject(s) - diabetic retinopathy , neovascularization , pathogenesis , medicine , microrna , choroidal neovascularization , diabetes mellitus , signal transduction , blood–retinal barrier , retinopathy , pathological , pathophysiology , angiogenesis , retinal , immunology , bioinformatics , pathology , cancer research , biology , ophthalmology , microbiology and biotechnology , endocrinology , gene , biochemistry
Diabetic retinopathy (DR) is one of the major complications of diabetes mellitus that causes diabetic macular edema and visual loss. DR is categorized, based on the presence of vascular lesions and neovascularization, into non‐proliferative and proliferative DR. Vascular changes in DR correlate with the cellular damage and pathological changes in the capillaries of blood‐retinal barrier. Several cytokines have been involved in inducing neovascularization. These cytokines activate different signaling pathways which are mainly responsible for the complications of DR. Recently; microRNAs (miRNAs) have been introduced as the key factors in the regulation of the cytokine expression which plays a critical role in neovascularization of retinal cells. Some studies have demonstrated that changing levels of miRNAs have essential role in the pathophysiology of vascular changes in patients with DR. The aim of this study is to identify the effects of miRNAs in the pathogenesis of DR via activating neovascularization pathways.