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Molecular evidence of role of vitamin D deficiency in various extraskeletal diseases
Author(s) -
Zendehdel Abolfazl,
Arefi Mohammad
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28185
Subject(s) - calcitriol receptor , vitamin d and neurology , calcitriol , immune system , endocrine system , vitamin d deficiency , endocrinology , hormone , vitamin , medicine , immunology
Background Role of vitamin D is not only limited to skeletal system but various other systems of the body, such as immune system, endocrine system, and cardiopulmonary system. Materials and Methods It is supported by the confirmations of systems‐wide expression of vitamin D receptor (VDR), endocrinal effect of calcitriol, and its role in immune responses. Results Expression of VDR in various systems, immunoregulatory and hormonal response of vitamin D and deficiency of vitamin D may establish various pathologies in the body. Conclusion This review provides molecular evidence of relation of vitamin D with extra skeletal.