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Possible mechanism of GATA4 inhibiting myocardin activity during cardiac hypertrophy
Author(s) -
Xu Yao,
Liang Chen,
Luo Ying,
Xing Weibing,
Zhang Tongcun
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28178
Subject(s) - myocardin , gata4 , downregulation and upregulation , mapk/erk pathway , microbiology and biotechnology , muscle hypertrophy , serum response factor , chemistry , cancer research , biology , signal transduction , endocrinology , biochemistry , transcription factor , gene
Myocardin is an important factor that regulates cardiac hypertrophy, and its activity can be regulated by GATA4. However, the molecular mechanism of the above process remains unclear. This paper presents three kinds of possible molecular mechanisms of GATA4 inhibiting myocardin activity in the process of cardiac hypertrophy. First, a competitive combination of GATA4 and SRF with myocardin could reduce the formation of the myocardin‐SRF‐CarG box complex when GATA4 was overexpressed. Second, overexpression of GATA4 could inhibit the combination of myocardin and p300 and downregulate acetylated myocardin levels. Finally, GATA4 could upregulate the phosphorylation of myocardin protein upon activation of the ERK pathway. These findings may provide insight into the function of GATA4 and myocardin in the occurrence and development of cardiac hypertrophy.