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Retracted : MicroRNA‐373 promotes the development of endometrial cancer by targeting LATS2 and activating the Wnt/β‐Catenin pathway
Author(s) -
Li Yan,
Sun Dongxia,
Gao Jie,
Shi Zhimin,
Chi Pengyu,
Meng Yuanyuan,
Zou Changjun,
Wang Yanhua
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28149
Subject(s) - wnt signaling pathway , microrna , cancer research , downregulation and upregulation , endometrial cancer , suppressor , catenin , cancer , biology , cell growth , signal transduction , medicine , microbiology and biotechnology , gene , genetics
In the female reproductive tract, endometrial cancer is the most common malignant tumor. Recently, the specific functions of many miRNAs have been identified in endometrial cancer. However, the contradictory effects of microRNA‐373 (miR‐373) in different human cancers draw our attention. In the present research, upregulation of miR‐373 was identified in endometrial cancer which predicted poor prognosis. Moreover, upregulation of miR‐373 promoted the migration, invasion, and proliferation of endometrial cancer cells. To further confirm that results, the EMT and Wnt/β‐Catenin pathways were also investigated, which were promoted by overexpression of miR‐373. Then, we further investigate the downstream factor, large tumor suppressor kinase 2 (LATS2) which was inhibited by miR‐373. LATS2 was verified as a direct target gene of miR‐373 through luciferase reporter assay. Especially, the facilitation of miR‐373 for cell proliferation, migration and invasion was impaired by LATS2. Taken together, miR‐373 promotes the progression of endometrial cancer through targeting LATS2 and promoting EMT and Wnt/β‐Catenin pathway.