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Long noncoding RNA HOXD‐AS2 regulates cell cycle to promote glioma progression
Author(s) -
Qi Yingjiao,
Wang Zhixing,
Wu Fan,
Yin Bin,
Jiang Tao,
Qiang Boqin,
Yuan Jiangang,
Han Wei,
Peng Xiaozhong
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28117
Subject(s) - glioma , long non coding rna , cancer research , cell cycle , biology , cell growth , cell , astrocyte , rna , gene , genetics , neuroscience , central nervous system
Now, numerous exciting findings have been found that long noncoding RNAs (lncRNAs) play a vital role in cancer malignant progression. However, their potential involvement in glioma is not well understood. Here, we performed a high‐throughput microarray to detect the lncRNA expression profiles between glioma cell lines and normal astrocyte cell lines. HOXD‐AS2 was increased in glioma cells and it was associated with glioma grade and poor prognosis. Loss of HOXD‐AS2 can inhibit glioma cell growth by inducing cell‐cycle G1 arrest in vitro. The proliferation of glioma was inhibited followed by knocking down the expression of HOXD‐AS2 not only in subcutaneous injection model but also in orthotopic implantation model. These findings indicate that HOXD‐AS2 promotes the glioma progression and may serve as a potential target for glioma diagnosis and therapy.