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Long noncoding RNA LINC00968 promotes endothelial cell proliferation and migration via regulating miR‐9‐3p expression
Author(s) -
Wang Xiaofeng,
Zhao Zheng,
Zhang Wei,
Wang Yi
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28103
Subject(s) - ectopic expression , downregulation and upregulation , cell growth , endothelial stem cell , long non coding rna , biology , pathogenesis , cell , microbiology and biotechnology , cancer research , microrna , cell migration , immunology , gene , genetics , in vitro
Long noncoding RNAs (lncRNAs) have been showed to play a crucial role in pathogenesis and development of cardiovascular diseases. Our study aimed to study the expression and functional role of lncRNA LINC00968 in the development of coronary artery disease (CAD). We showed that the LINC00968 expression level was upregulated in the CAD tissues compared with normal arterial tissues. In addition, we showed that the expression level of LINC00968 was upregulated by oxidized low‐density lipoprotein (oxLDL) treatment in endothelial cell. Ectopic expression of LINC00968 regulated the proliferation and migration of endothelial cell. Moreover, we showed that overexpression of LINC00968 inhibited miR‐9‐3p expression in an endothelial cell. Furthermore, we demonstrated that the miR‐9‐3p expression was downregulated in the CAD samples compared with normal arterial tissues and the expression level of miR‐9‐3p was downregulated by oxLDL treatment in endothelial cell. Finally, we showed that ectopic expression of LINC00968 promoted endothelial cell proliferation and migration partly through regulating miR‐9‐3p expression. These results suggested that LINC00968 plays a crucial role in the progression of the CAD.