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Long noncoding RNA POU3F3 promotes cancer cell proliferation in prostate carcinoma by upregulating rho‐associated protein kinase 1
Author(s) -
Wan Xiaodong,
Xiang Jun,
Zhang Qimin,
Bian Cuidong
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28101
Subject(s) - rock1 , gene knockdown , cancer research , cell growth , prostate cancer , metastasis , biology , prostate , kinase , cancer , protein kinase a , medicine , microbiology and biotechnology , cell culture , genetics
Long noncoding RNAs (lncRNAs) POU3F3 is overexpressed in esophageal squamous‐cell carcinomas, while its role in other human cancers is unclear. In this study we found that POU3F3 and rho‐associated protein kinase 1 (ROCK1) were both increased in tumor tissues than in adjacent healthy tissues of patients with prostate carcinoma. Expression levels of POU3F3 increased with increase in the diameter of tumor but were not significantly affected by lymph node metastasis or distant metastasis. Expression levels of POU3F3 and ROCK1 were positive correlated in tumor tissues but not in adjacent healthy tissues. POU3F3 and ROCK1 overexpression promoted, while ROCK1 knockdown inhibited the proliferation of prostate carcinoma cells. ROCK1 knockdown reduced the enhancing effect of POU3F3 overexpression on cancer cell proliferation. POU3F3 overexpression led to ROCK1 overexpression in prostate carcinoma cells, while ROCK1 overexpression did not significantly affect POU3F3 expression. Therefore, lncRNA POU3F3 may promote cancer cell proliferation in prostate carcinoma by upregulating ROCK1.