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USP28 contributes to the proliferation and metastasis of gastric cancer
Author(s) -
Zhao LiJuan,
Zhang Ting,
Feng XueJian,
Chang Jiao,
Suo FengZhi,
Ma JinLian,
Liu YingJun,
Liu Ying,
Zheng YiChao,
Liu HongMin
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28040
Subject(s) - deubiquitinating enzyme , cancer , cancer research , cancer cell , apoptosis , metastasis , cell growth , oncogene , biology , medicine , ubiquitin , cell cycle , gene , biochemistry
USP28, a member of the deubiquitinating enzymes family, plays a vital role in the physiological process of cell proliferation, differentiation and apoptosis, DNA repair, immune response, and stress response. USP28 has been reported to be overexpressed in bladder cancer, colon cancer, breast carcinomas, and so on. Nevertheless, the role of USP28 in gastric cancer has not yet been investigated. In our study, we examined the USP28 expression in 87 paired samples of gastric cancer and normal gastric tissues. We found that USP28 was overexpressed in gastric cancer compared with normal gastric tissues ( P < 0.01), and its overexpression was related to the degree of differentiation and metastases. Inhibiting USP28 expression in vitro suppressed the proliferation and invasion of gastric cancer cells by downregulating lysine specific demethylase 1. On the basis of our data, it can be concluded that USP28 may be a novel therapeutic target for gastric cancer.