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LncRNA OIP5‐AS1 predicts poor prognosis and regulates cell proliferation and apoptosis in bladder cancer
Author(s) -
Wang Yang,
Shi Fu,
Xia Yong,
Zhao Huacai
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.28024
Subject(s) - downregulation and upregulation , bladder cancer , cancer research , antisense rna , biology , apoptosis , cancer , cell growth , long non coding rna , cell , rna , gene , biochemistry , genetics
Opa‐interacting protein 5 antisense RNA 1 (OIP5‐AS1) is a long intergenic noncoding RNA, which has been suggested to be dysregulated in human cancers and served as tumor suppressor or promoter depending on tumor types. However, the role of OIP5‐AS1 in bladder cancer was still unknown. In our study, OIP5‐AS1 was overexpressed in bladder cancer, and associated with clinical progression and short overall survival. The loss‐of‐function studies suggested downregulation of OIP5‐AS1 expression decreased cell viability, induced cell‐cycle arrest and promoted cell apoptosis in bladder cancer. There was a positive association between OIP5‐AS1 expression and OIP5 expression in bladder cancer tissues. Moreover, downregulation of OIP5‐AS1 expression reduced messenger RNA and protein levels of OIP5 in bladder cancer cell lines. In conclusion, OIP5‐AS1 is a useful biomarker for predicting clinical progression and poor prognosis and promotes cell proliferation through modulating OIP5 expression.