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Facile and greener hydrothermal honey‐based synthesis of Fe 3 O 4 /Au core/shell nanoparticles for drug delivery applications
Author(s) -
Rasouli Elisa,
Basirun Wan Jeffrey,
Johan Mohd Rafie,
Rezayi Majid,
Darroudi Majid,
Shameli Kamyar,
Shanavaz Zohreh,
Akbarzadeh Omid,
Izadiyan Zahra
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27958
Subject(s) - selected area diffraction , nuclear chemistry , transmission electron microscopy , nanoparticle , fourier transform infrared spectroscopy , hydrothermal circulation , spectroscopy , energy dispersive x ray spectroscopy , materials science , scanning electron microscope , powder diffraction , analytical chemistry (journal) , nanotechnology , chemical engineering , chemistry , crystallography , organic chemistry , physics , quantum mechanics , engineering , composite material
In the present research, we report a greener, faster, and low‐cost synthesis of gold‐coated iron oxide nanoparticles (Fe 3 O 4 /Au‐NPs) by different ratios (1:1, 2:1, and 3:1 molar ratio) of iron oxide and gold with natural honey (0.5% w/v) under hydrothermal conditions for 20 minutes. Honey was used as the reducing and stabilizing agent, respectively. The nanoparticles were characterized by X‐ray diffraction (XRD), UV‐visible spectroscopy, field emission scanning electron microscope (FESEM), energy‐dispersive X‐ray spectroscopy (EDXS), transmission electron microscopy (TEM), selected area electron diffraction (SAED), vibrating sample magnetometer (VSM), and fourier transformed infrared spectroscopy (FT‐IR). The XRD analysis indicated the presence of Fe 3 O 4 /Au‐NPs, while the TEM images showed the formation of Fe 3 O 4 /Au‐NPs with diameter range between 3.49 nm and 4.11 nm. The VSM study demonstrated that the magnetic properties were decreased in the Fe 3 O 4 /Au‐NPs compared with the Fe 3 O 4 ‐NPs. The cytotoxicity threshold of Fe 3 O 4 /Au‐NPs in the WEHI164 cells was determined by using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay. It was demonstrated no significant toxicity in higher concentration up to 140.0 ppm which can become the main candidates for biological and biomedical applications, such as drug delivery.