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The role of IL‐3 in bone
Author(s) -
Soysa Niroshani Surangika,
Alles Neil
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27956
Subject(s) - cytokine , bone marrow aplasia , immunology , haematopoiesis , rheumatoid arthritis , bone marrow , medicine , cancer research , biology , microbiology and biotechnology , stem cell
Abstract In the recent past, there has been a burgeoning interest in targeting cytokines such as IL‐3 for specific disease conditions of bone such as rheumatoid arthritis and multiple myeloma. Unlike other cytokines, IL‐3 is a cytokine with a multilineage potential and broad spectrum of target cells and it plays a vital role in hematopoiesis. Due to its common receptor subunit, the action of IL‐3 shows functional redundancy with other cytokines such as the granulocyte‐macrophage colony‐stimulating factor and IL‐5. IL‐3 has been successfully used in ameliorating radiation‐induced bone marrow aplasia and similar conditions. However, the role of IL‐3 in bone cells has not been fully unraveled yet; therefore, the aim of this overview is to present the effects of IL‐3 in bone with a special emphasis on osteoclasts and osteoblasts in a concise manner.