Premium
β‐Sitosterol improves experimental colitis in mice with a target against pathogenic bacteria
Author(s) -
Ding Kang,
Tan YanYan,
Ding Yang,
Fang Yuan,
Yang Xu,
Fang Jian,
Xu DaChao,
Zhang Hui,
Lu Wei,
Li Meng,
Huang ShiCai,
Cai MengLing,
Song Yan,
Ding YiJiang,
Zhang SuMin
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.27853
Subject(s) - colitis , bacteria , pathogenic bacteria , microbiology and biotechnology , inflammation , intracellular , salmonella , dextran , chemistry , biology , immunology , biochemistry , genetics
In this article, we aim to examine the novel effects of β‐sitosterol on murine experimental colitis. β‐Sitosterol significantly reduces the weight loss, colon length, and alleviated microscopic appearances of colitis induced by dextran sulfate sodium. This compound also decreases the levels of TNF‐α, IL‐6, and IL‐1β in intestinal tissue of mice with experimental colitis in a concentration‐dependent manner. β‐Sitosterol treatment to intestinal epithelial cells significantly increases expression of antimicrobial peptides and reduces survival of intracellular Salmonella typhimurium . These results showed the multiple effects of β‐sitosterol against pathogenic bacteria for a novel approach to the treatment of colonic inflammation.